Dr. Martin Harris and his wife Liz arrive in Berlin for a biotechnology summit. However, upon arriving at Hotel Adlon, Martin realizes his briefcase was left at the airport. He takes a taxicab driven by a woman named Gina, but on the way to the airport, the cab crashes off a bridge into the river. Martin is knocked unconscious upon impact, but Gina saves him from drowning before fleeing from the scene to avoid the police, since she is an illegal immigrant from Bosnia. On Thanksgiving day, Martin regains consciousness at the hospital after being in a coma for four days.
Martin returns to his hotel, only to discover another man with his wife, who claims she doesn't know him. He attempts to contact his old colleague Prof. Rodney Cole, who is unavailable due to Thanksgiving in the U.S. Martin then heads to the office of Prof. Leo Bressler, whom he is scheduled to meet that day. However, he sees the impostor, "Martin B," already in a meeting with Bressler. As Martin attempts to prove his identity, Martin B shows him his ID and family photo – both of which have Martin's name, only with his face replaced by that of the impostor. Disillusioned by the identity crisis, Martin falls unconscious and finds himself back at the hospital. Smith, an assassin sent to target him, kills Nurse Gretchen Erfurt, but Martin escapes.
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